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Refers to CPUs that use 64-bit words. Examples are Sun's UltraSPARC series, the G5 processors in the Macintosh and Intel's Itanium family.

     In the x86 PC world, AMD was the first to move to 64-bit CPUs with its 2003 introductions of the AMD64 Opteron and Athlon chips. Microsoft added support in Windows XP for AMD's 64-bit instructions (AMD64). Although Intel featured 64 bits in its Itanium line, in response to AMD, it introduced 64-bit x86-based Xeon CPUs in 2004. The 64 bit CPUs were first called "Extended Memory 64 Technology" (EM64T), but later changed to "Intel 64." Intel 64 chips incorporate AMD's 64-bit instructions. See bit specifications, Intel 64, Opteron, Athlon, UltraSPARC and G5.